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Hantaviruses induce cytopathic effects and apoptosis in continuous human embryonic kidney cells

16 Jul 2003

Abstract excerpt

Hantaviruses are maintained in nature in persistently infected rodents and can also persistently infect cultured mammalian cells, causing little or no cytopathology. An unexpected outcome of this study was the observation of cytopathic effects (CPE) in the hantavirus-infected human embryonic kidney cell line HEK293. It was confirmed that hantaviruses induce apoptosis in HEK293 cells, although apoptosis appeared...

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PMID: 12867652
DOI: 10.1099/vir.0.19090-0

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