Article
Mutations in the glycoprotein of vesicular stomatitis virus affect cytopathogenicity: potential for oncolytic virotherapy.
Journal of virology - 1 Jul 2011
Janelle Valérie, Brassard Frédérick, Lapierre Pascal, Lamarre Alain, Poliquin Laurent
Abstract excerpt
Vesicular stomatitis virus (VSV) has been widely used to characterize cellular processes, viral resistance, and cytopathogenicity. Recently, VSV has also been used for oncolytic virotherapy due to its capacity to selectively lyse tumor cells. Mutants of the matrix (M) protein of VSV have generally been preferred to the wild-type virus for oncolysis because of their ability to induce type I interferon (IFN)...
Topics
- Animals
- Cell Line, Tumor
- Chlorocebus aethiops
- Cytopathogenic Effect, Viral
- Fibroblasts
- Humans
- L Cells
- Membrane Glycoproteins
- Mice
- Molecular Sequence Data
- Mutation
- Oncolytic Virotherapy
- Oncolytic Viruses
- Sequence Analysis, DNA