Article
Mycobacterium tuberculosis short mutant H37Rv-S with reduced growth adaptability is more readily recognized by the host immune system.
Microbial pathogenesis - 1 Jan 2025
Dong Jilin, Li Guilian, Wang Jiahao, Liu Bingbing, Xiang Yu, Jiang Songhao, Shi Jiahui, Wu Wenhui, Wang Guibin, Chang Lei, Wu Chen, Liu Haican, Xu Ping, Zhang Yao
Abstract excerpt
Mycobacterium tuberculosis (Mtb) is the bacterium responsible for causing Tuberculosis (TB) and understanding its mechanisms of virulence, persistence, and pathogenesis is a global research priority. Attenuated strains of Mtb are valuable tools for investigating the genes and proteins involved in these processes. In this study, we identified an Mtb mutant, H37Rv-S, which exhibits a shorter mycelium, smoother...
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