Article
Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum.
Biochimica et biophysica acta - 1 Nov 2010
Thorne Rick F, Ralston Kylie J, de Bock Charles Edo, Mhaidat Nizar M, Zhang Xu Dong, Boyd Andrew W, Burns Gordon F
Abstract excerpt
CD36/FAT is a transmembrane glycoprotein that functions in the cellular uptake of long-chain fatty acids and also as a scavenger receptor. As such it plays an important role in lipid homeostasis and, pathophysiologically, in the progression of type 2 diabetes and atherosclerosis. CD36 expression is tightly regulated at the levels of both transcription and translation. Here we show that its expression and location...
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