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Article

Effects of Immunization with CCR5-Based Cycloimmunogen on Simian/HIVSF162P3 Challenge

1 Jan 2006

Abstract excerpt

A synthetic cycloimmunogen targeting the HIV-1 coreceptor CCR5 was evaluated for its capacity to induce CCR5-specific Abs with anti-HIV-1 activity in cynomolgus macaques. The cyclic closed-chain dodecapeptide (cDDR5) mimicking the conformation-specific domain of human CCR5 was chemically prepared, in which the Gly-Glu dipeptide links the amino and carboxy termini of the decapeptidyl linear chain (Arg168 to...

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PMID: 16365439
DOI: 10.4049/jimmunol.176.1.463

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