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A CCHFV DNA vaccine protects against heterologous challenge and establishes GP38 as immunorelevant in mice

2 Mar 2021

Abstract excerpt

Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic fever disease in humans. Currently, no licensed CCHF vaccines exist, and the protective epitopes remain unclear. Previously, we tested a DNA vaccine expressing the M-segment glycoprotein precursor gene of the laboratory CCHFV strain IbAr 10200 (CCHFV-M 10200 ). CCHFV-M 10200 provided >60% protection against...

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PMID: 33654101
DOI: 10.1038/s41541-021-00293-9

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