Article
The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling.
Cancer research - 15 Dec 2005
Sawai Hirozumi, Okada Yuji, Kazanjian Kevork, Kim Joseph, Hasan Sascha, Hines Oscar J, Reber Howard A, Hoon Dave S B, Eibl Guido
Abstract excerpt
Mutations of the RET proto-oncogene are responsible for several inherited human diseases and may function as genetic modifiers of the disease. However, the role of RET mutations in pancreatic cancer has not been studied. Expression of the glial cell line-derived neurotrophic factor (GDNF) receptors RET and GDNF family receptor alpha1 (GFRalpha1) in human pancreatic cancer cells was determined by Western blot,...
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