Article
The RET G691S polymorphism is a germline variant in desmoplastic malignant melanoma.
Melanoma research - 1 Feb 2012
Barr Jodie, Amato Carol M, Robinson Steven E, Kounalakis Nicole, Robinson William A
Abstract excerpt
The RET protooncogene was originally identified in 1985. It encodes for a receptor tyrosine kinase. The RET receptor is activated by its ligand glial cell-derived neurotrophic factor. A polymorphism, RETp (G691S), in the intracellular juxtamembrane domain of RET, which enhances signaling by glial cell-derived neurotrophic factor has been described and studied previously in pancreatic cancer, medullary thyroid...
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