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Article

Complex genetic predisposition to cancer in an extended HNPCC family with an ancestral hMLH1 mutation.

Journal of medical genetics - 1 Aug 1996

Hutter P, Couturier A, Scott R J, Alday P, Delozier-Blanchet C, Cachat F, Antonarakis S E, Joris F, Gaudin M, D'Amato L, Buerstedde J M

Abstract excerpt

Hereditary non-polyposis colorectal cancer (HNPCC) is characterised by a genetic predisposition to develop colorectal cancer at an early age and, to a lesser degree, cancer of the endometrium, ovaries, urinary tract, and organs of the gastrointestinal tract other than the colon. In the majority of families the disease is linked to mutations in one of the two mismatch repair genes, hMSH2 or hMLH1. We have found a...

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Identifiers

PMID: 8863153
DOI: 10.1136/jmg.33.8.636
PMCID: PMC1050695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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