Article
The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans.
Development (Cambridge, England) - 1 Jan 2006
Kubota Yukihiko, Sano Mitsue, Goda Saori, Suzuki Norio, Nishiwaki Kiyoji
Abstract excerpt
In C. elegans, the gonad acquires two U-shaped arms through directed migration of gonadal distal tip cells (DTCs). A member of the ADAM (a disintegrin and metalloprotease) family, MIG-17, is secreted from muscle cells and localizes to the gonadal basement membrane where it functions in DTC migration. Mutations in cogc-3 and cogc-1 cause misdirected DTC migration similar to that seen in mig-17 mutants. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.