Article
A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans.
Current biology : CB - 23 Nov 2004
Kubota Yukihiko, Kuroki Rie, Nishiwaki Kiyoji
Abstract excerpt
ADAM (a disintegrin and metalloprotease) family proteins play important roles in animal development and pathogenesis. In C. elegans, a secreted ADAM protein, MIG-17, acts from outside the gonad to control the migration of gonadal distal tip cells (DTCs) that promote gonad morphogenesis. Here, we report that dominant mutations in the fbl-1 gene encoding fibulin-1 spliced isoforms, which are calcium binding...
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