Article
Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis.
Journal of cell science - 15 Nov 2012
Belloni Giorgio, Sechi Stefano, Riparbelli Maria Giovanna, Fuller Margaret T, Callaini Giuliano, Giansanti Maria Grazia
Abstract excerpt
The conserved oligomeric Golgi (COG) complex plays essential roles in Golgi function, vesicle trafficking and glycosylation. Deletions in the human COG7 gene are associated with a rare multisystemic congenital disorder of glycosylation that causes mortality within the first year of life. In this...
Topics
- Amino Acid Sequence
- Animals
- Axoneme
- Cytokinesis
- Drosophila Proteins
- Drosophila melanogaster
- Genes, Insect
- Glycoconjugates
- Golgi Apparatus
- Humans
- Larva
- Male
- Meiosis
- Molecular Sequence Data
- Mutation
- Spermatids
- Spermatocytes
- Spermatogenesis