Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distal tip cell migration mutants of Caenorhabditis elegans are rescued by bioequivalent outputs from chondroitin and N-glycosylation pathways.

The Journal of biological chemistry - 1 Dec 2025

Dennis James W, Dunn Robert J, Levy-Strumpf Naomi, Brooun Maria, Moghal Nadeem, Culotti Joseph G

Abstract excerpt

In Caenorhabditis elegans, gonadal morphogenesis begins with the post-embryonic birth of two distal tip cells (DTCs) that migrate in phase 1 along the ventral body-wall in opposite directions. Phase 2 comprises a 90° turn followed by migration in a dorsal direction. Here, we identify a genetic dependency between two glycosylation pathways that modify proteins at different sites and display bioequivalence that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Movement

Share to Glycosylation

Share to Mutation

Share to N-Acetylgalactosaminyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 41197717
DOI: 10.1016/j.jbc.2025.110895
PMCID: PMC12721165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distal tip cell migration mutants of Caenorhabditis elegans are rescued by bioequivalent outputs from chondroitin and N-glycosylation pathways.PMID 41197717Read ↗

The directed migration of gonadal distal tip cells in Caenorhabditis elegans requires NGAT-1, a ß1,4-N-acetylgalactosaminyltransferase enzyme.Semantic proximity Read ↗

Ablation of N-acetylglucosaminyltransferases in Caenorhabditis induces expression of unusual intersected and bisected N-glycans.Semantic proximity Read ↗

The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans.Semantic proximity Read ↗

<i>O</i> -GlcNAc transferase plays a non-catalytic role in <i>C. elegans</i> male fertilitySemantic proximity Read ↗

O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder.Semantic proximity Read ↗

An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans.Semantic proximity Read ↗

Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model.Semantic proximity Read ↗

COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes.Semantic proximity Read ↗

Combinatorial roles of heparan sulfate proteoglycans and heparan sulfates in Caenorhabditis elegans neural development.Semantic proximity Read ↗

Modeling a congenital disorder of glycosylation type I in C. elegans: a genome-wide RNAi screen for N-glycosylation-dependent loci.Semantic proximity Read ↗

The C. elegans hyaluronidase: a developmentally significant enzyme with chondroitin-degrading activity at both acidic and neutral pH.Semantic proximity Read ↗

Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.