Article
The directed migration of gonadal distal tip cells in Caenorhabditis elegans requires NGAT-1, a ß1,4-N-acetylgalactosaminyltransferase enzyme.
PloS one - 1 Jan 2017
Veyhl Joseph, Dunn Robert J, Johnston Wendy L, Bennett Alexa, Zhang Lijia W, Dennis James W, Schachter Harry, Culotti Joseph G
Abstract excerpt
Glycoproteins such as growth factor receptors and extracellular matrix have well-known functions in development and cancer progression, however, the glycans at sites of modification are often heterogeneous molecular populations which makes their functional characterization challenging. Here we provide evidence for a specific, discrete, well-defined glycan modification and regulation of a stage-specific cell...
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