Article
Candidate gene approach identifies multiple genes and signaling pathways downstream of Tbx4 in the developing allantois.
PloS one - 1 Jan 2012
Arora Ripla, del Alcazar Chelsea M, Morrisey Edward E, Naiche L A, Papaioannou Virginia E
Abstract excerpt
Loss of Tbx4 results in absence of chorio-allantoic fusion and failure of formation of the primary vascular plexus of the allantois leading to embryonic death at E10.5. We reviewed the literature for genes implicated in chorio-allantoic fusion, cavitation and vascular plexus formation, processes affected in Tbx4 mutant allantoises. Using this candidate gene approach, we identified a number of genes downstream of...
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