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<i>MTHFR</i>Gene variants C677T, A1298C and association with Down syndrome: A case-control study from South India

1 Jan 2009

Abstract excerpt

BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and low folate levels are associated with inhibition of DNA methyltransferase and consequently DNA hypomethylation. The expanding spectrum of common conditions linked with MTHFR polymorphisms includes certain adverse birth outcome, pregnancy complications, cancers, adult cardiovascular diseases and psychiatric disorders, with several...

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PMID: 20680153
DOI: 10.4103/0971-6866.55217

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