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Maternal MTHFR 677C>T, 1298A>C gene polymorphisms and risk of offspring aneuploidy.

Prenatal diagnosis - 1 Aug 2022

Miljanović Olivera, Teofilov Slađana, Anđelić Miljana, Magić Zvonko, Cikota-Aleksić Bojana

Abstract excerpt

OBJECTIVE: The objective was to investigate the association between maternal methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms, crucial for DNA methylation, and risk of offspring aneuploidy. METHODS: MTHFR gene polymorphisms 677C>T and 1298A>C were determined by polymerase chain reaction based method, in 163 women with offspring aneuploidy and 155 women with healthy children. Five genetic models were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35856339
DOI: 10.1002/pd.6214

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