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Comparative analysis of cancer gene mutations using targeted sequencing in matched primary and recurrent gastric cancers after chemotherapy.

Genes & genomics - 1 Nov 2022

Huh Yeon-Ju, Cho Sung-Yup, Cho Min-Sun, Lee Kyoung-Eun, Lee Joo-Ho

Abstract excerpt

BACKGROUND: Investigation of responsiveness-associated genes using longitudinal mutation analyses after standard treatments in recurrent gastric cancer (GC) is limited. OBJECTIVE: To evaluate the somatic mutations associated with resistance to combined treatment involving fluorouracil (FU) or platinum (PL) in advanced GC. METHODS: Samples from patients with advanced GC treated with FU or PL alone, or surgery plus...

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PMID: 35622232
DOI: 10.1007/s13258-022-01248-7

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