Differential synthesis of two interleukin-1 receptor antagonist variants and interleukin-8 by peripheral blood neutrophils.

doi:10.1016/j.cyto.2005.10.004

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Article

Differential synthesis of two interleukin-1 receptor antagonist variants and interleukin-8 by peripheral blood neutrophils.

Cytokine - 7 Dec 2005

Schröder Anja K, von der Ohe Maren, Fleischer Daniela, Rink Lothar, Uciechowski Peter

Abstract excerpt

With a short lifespan and containing only few ribosomes and endoplasmic reticulum structures, neutrophils are thought to have a limited capacity for protein synthesis. We here show that peripheral blood polymorphonuclear neutrophils (PMN) are able react to stimulants with differential production of two interleukin (IL)-1 receptor antagonist (IL-1ra) isoforms, secreted IL-1ra (sIL-1ra) and the 16kDa intracellular...

Topics

Genetic Variation
Humans
Interleukin 1 Receptor Antagonist Protein
Interleukin-8
Neutrophils
Polymerase Chain Reaction
Protein Isoforms
RNA, Messenger
Receptors, Interleukin-1
Sialoglycoproteins
Subcellular Fractions

Source

Open in PubMed

Identifiers

PMID: 16343927
DOI: 10.1016/j.cyto.2005.10.004

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