Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cloning, expression, and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humans.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2009

Li Tingting, Woods James S

Abstract excerpt

Coproporphyrinogen oxidase (CPOX) catalyzes the two-step decarboxylation of coproporphyrinogen-III to protoporphyrinogen-IX in the heme biosynthetic pathway. Previously we described a specific polymorphism (A814C) in exon 4 of the human CPOX gene (CPOX4) and demonstrated that CPOX4 is associated with both modified urinary porphyrin excretion and increased neurobehavioral deficits among human subjects with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, High Pressure Liquid
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Stability

Share to Escherichia coli

Share to Kinetics

Share to Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19339664
DOI: 10.1093/toxsci/kfp066
PMCID: PMC2683923

Genes

CPOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cloning, expression, and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humans.PMID 19339664Read ↗

A molecular defect in coproporphyrinogen oxidase gene causing harderoporphyria, a variant form of hereditary coproporphyria.Semantic proximity Read ↗

The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humansSemantic proximity Read ↗

Molecular abnormalities of coproporphyrinogen oxidase in patients with hereditary coproporphyria.Semantic proximity Read ↗

The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans.Semantic proximity Read ↗

Environment-dependent landscapes of coding variant impacts on coproporphyrinogen oxidaseSemantic proximity Read ↗

Hereditary coproporphyria.Semantic proximity Read ↗

Modification of neurobehavioral effects of mercury by a genetic polymorphism of coproporphyrinogen oxidase in children.Semantic proximity Read ↗

Characterization of mutations in the CPO gene in British patients demonstrates absence of genotype-phenotype correlation and identifies relationship between hereditary coproporphyria and harderoporphyria.Semantic proximity Read ↗

Mutations in human CPO gene predict clinical expression of either hepatic hereditary coproporphyria or erythropoietic harderoporphyria.Semantic proximity Read ↗

The enzyme engineering of mutant homodimer and heterodimer of coproporphyinogen oxidase contributes to new insight into hereditary coproporphyria and harderoporphyria.Semantic proximity Read ↗

Biochemical and genetic characterization of four cases of hereditary coproporphyria in Spain.Semantic proximity Read ↗

Three novel mutations in the coproporphyrinogen oxidase gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.