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Article

Association between glutathione S-transferase pi polymorphisms and survival in patients with advanced nonsmall cell lung carcinoma.

Cancer - 15 Jan 2006

Lu Charles, Spitz Margaret R, Zhao Hua, Dong Qiong, Truong Mylene, Chang Joe Y, Blumenschein George R, Hong Waun K, Wu Xifeng

Abstract excerpt

BACKGROUND: Glutathione S-transferase (GST) pi (GSTP1) is a detoxification enzyme with substrate specificity for both exogenous carcinogens and chemotherapy agents. Genetic polymorphisms of GSTP1 exon 5 (Ile105Val) and exon 6 (Ala114Val) appear to reduce this enzyme's activity. Previously, the authors reported that the exon 6 variant was associated with an increased risk of lung carcinoma, particularly among men,...

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Source

Identifiers

PMID: 16342067
DOI: 10.1002/cncr.21619

Genes

GSTP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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