Article
Genetic Variation in GSTP1, Lung Function, Risk of Lung Cancer, and Mortality.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2017
Nørskov Marianne S, Dahl Morten, Tybjærg-Hansen Anne
Abstract excerpt
INTRODUCTION: Glutathione S-transferase pi 1 metabolizes carcinogens from tobacco smoke in the lung. We tested whether genetically altered glutathione S-transferase pi 1 activity affects lung function and risk for tobacco-related cancer and mortality in the general population. METHODS: We genotyped 66,069 individuals from the white general population for two common functional variants in the glutathione...
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