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Article

An mRNA-rRNA base-pairing mechanism for translation initiation in eukaryotes.

Nature structural & molecular biology - 1 Jan 2006

Dresios John, Chappell Stephen A, Zhou Wei, Mauro Vincent P

Abstract excerpt

Base-pairing of messenger RNA to ribosomal RNA is a mechanism of translation initiation in prokaryotes. Although analogous base-pairing has been suggested to affect the translation of various eukaryotic mRNAs, direct evidence has been lacking. To test such base-pairing, we developed a yeast system that uses ribosomes containing a mouse-yeast hybrid 18S rRNA. Using this system, we demonstrate that a 9-nucleotide...

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Share to Saccharomyces cerevisiae
Share to Base Pairing
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peptide Chain Initiation, Translational

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Identifiers

PMID: 16341227
DOI: 10.1038/nsmb1031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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