Lgi4 Promotes the Proliferation and Differentiation of Glial Lineage Cells throughout the Developing Peripheral Nervous System

Abstract excerpt

The mechanisms that regulate peripheral nervous system (PNS) gliogenesis are incompletely understood. For example, gut neural crest stem cells (NCSCs) do not respond to known gliogenic factors, suggesting that yet-unidentified factors regulate gut gliogenesis. To identify new mechanisms, we performed gene expression profiling to identify factors secreted by gut NCSCs during the gliogenic phase of development....

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