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Article

An antiviral role for the RNA interference machinery in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005

Schott Daniel H, Cureton David K, Whelan Sean P, Hunter Craig P

Abstract excerpt

RNA interference (RNAi) is a sequence-specific gene-silencing mechanism triggered by exogenous dsRNA. In plants an RNAi-like mechanism defends against viruses, but the hypothesis that animals possess a similar natural antiviral mechanism related to RNAi remains relatively untested. To test whether genes needed for RNAi defend animal cells against virus infection, we infected wild-type and RNAi-defective cells of...

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Identifiers

PMID: 16339901
DOI: 10.1073/pnas.0507123102
PMCID: PMC1317933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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