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Article

An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans.

mBio - 5 Sept 2017

Tanguy Mélanie, Véron Louise, Stempor Przemyslaw, Ahringer Julie, Sarkies Peter, Miska Eric A

Abstract excerpt

Across metazoans, innate immunity is vital in defending organisms against viral infection. In mammals, antiviral innate immunity is orchestrated by interferon signaling, activating the STAT transcription factors downstream of the JAK kinases to induce expression of antiviral effector genes. In the nematode Caenorhabditis elegans, which lacks the interferon system, the major antiviral response so far described is...

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Identifiers

PMID: 28874466
DOI: 10.1128/mBio.00924-17
PMCID: PMC5587905

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