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Article

RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in <i>Drosophila</i>

26 Oct 2010

Abstract excerpt

Activation of innate antiviral responses in multicellular organisms relies on the recognition of structural differences between viral and cellular RNAs. Double-stranded (ds)RNA, produced during viral replication, is a well-known activator of antiviral defenses and triggers interferon production in vertebrates and RNAi in invertebrates and plants. Previous work in mammalian cells indicates that negative-strand RNA...

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PMID: 20978209
DOI: 10.1073/pnas.1014378107

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