Article
Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses.
PLoS biology - 25 Jan 2011
Félix Marie-Anne, Ashe Alyson, Piffaretti Joséphine, Wu Guang, Nuez Isabelle, Bélicard Tony, Jiang Yanfang, Zhao Guoyan, Franz Carl J, Goldstein Leonard D, Sanroman Mabel, Miska Eric A, Wang David
Abstract excerpt
An ideal model system to study antiviral immunity and host-pathogen co-evolution would combine a genetically tractable small animal with a virus capable of naturally infecting the host organism. The use of C. elegans as a model to define host-viral interactions has been limited by the lack of viruses known to infect nematodes. From wild isolates of C. elegans and C. briggsae with unusual morphological phenotypes...
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