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Article

Characterizing the role of RSD-6 in the biogenesis of virus-derived small interfering RNAs and the modulation of viral pathogenesis.

Journal of virology - 20 Jan 2026

Dahal Krishna, Xia Mingli, Lu Jinfeng, Yan Teng, Lu Rui

Abstract excerpt

Small interfering RNAs (siRNAs) produced through the processing of viral double-stranded RNAs mediate potent antiviral RNA interference (RNAi) in eukaryotes. In Caenorhabditis elegans, such an antiviral defense is further amplified through the production of secondary siRNAs, yet the mechanisms by which secondary virus-derived siRNAs (vsiRNAs) confer protection remain poorly understood. Here, we characterize the...

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Identifiers

PMID: 41384733
DOI: 10.1128/jvi.01516-25
PMCID: PMC12817956

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