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Article

An SRR1 domain-containing protein is required for efficient Orsay virus replication in Caenorhabditis elegans.

Journal of virology - 23 Sept 2025

Fujii Chika, Wang David

Abstract excerpt

Viruses depend on their hosts for completing their life cycle, and a better understanding of virus replication can inform therapeutic strategies. Using the Orsay virus-Caenorhabditis elegans experimental platform, we identified by a forward genetic screen the host gene Y55F3BL.4 (renamed viro-9) as a novel host factor critical for Orsay virus replication. Three distinct mutations of viro-9 each resulted in a...

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Identifiers

PMID: 40899816
DOI: 10.1128/jvi.00521-25
PMCID: PMC12455975

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