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Article

Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans.

PLoS biology - 1 Jan 2025

Seetharaman Ashwin, Galagali Himani, Linarte Elizabeth, Liu Mona H X, Cohen Jennifer D, Chetal Kashish, Sadreyev Ruslan, Tate Alex J, Montgomery Taiowa A, Ruvkun Gary

Abstract excerpt

RNA interference (RNAi) mediates antiviral defense in many eukaryotes. Caenorhabditis elegans mutants that disable RNAi are more sensitive to viral infection. Many mutants that enhance RNAi have also been identified; these mutations may reveal genes that are normally down-regulated in antiviral defense. About one-third of the score of mutants that enhance RNAi are in synMuv B genes, identified 30 years ago in...

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Topics

Animals
Caenorhabditis elegans
RNA Interference
Caenorhabditis elegans Proteins
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Nodaviridae

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Identifiers

PMID: 39879188
DOI: 10.1371/journal.pbio.3002748
PMCID: PMC11778786

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