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Article

Analysis of human alpha globin gene mutations that impair binding to the alpha hemoglobin stabilizing protein.

Blood - 4 Jun 2009

Yu Xiang, Mollan Todd L, Butler Andrew, Gow Andrew J, Olson John S, Weiss Mitchell J

Abstract excerpt

Alpha hemoglobin stabilizing protein (AHSP) reversibly binds nascent alpha globin to maintain its native structure and facilitate its incorporation into hemoglobin A. Previous studies indicate that some naturally occurring human alpha globin mutations may destabilize the protein by inhibiting its interactions with AHSP. However, these mutations could also affect hemoglobin A production through AHSP-independent...

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Identifiers

PMID: 19349619
DOI: 10.1182/blood-2008-12-196030
PMCID: PMC2700329

Genes

AHSP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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