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Pim1 kinase regulates c-Kit gene translation

1 Dec 2016

Abstract excerpt

Receptor tyrosine kinase, c-Kit (CD117) plays a pivotal role in the maintenance and expansion of hematopoietic stem/progenitor cells (HSPCs). Additionally, over-expression and/or mutational activation of c-Kit have been implicated in numerous malignant diseases including acute myeloid leukemia. However, the translational regulation of c-Kit expression remains largely unknown. We demonstrated that loss of Pim1 led...

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PMID: 28042518
DOI: 10.1186/s40164-016-0060-3

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