Common variants in the lipoprotein lipase gene, but not those in the insulin receptor substrate-1, the beta3-adrenergic receptor, and the intestinal fatty acid binding protein-2 genes, influence the lipid phenotypic expression in familial combined hyperlipidemia.

doi:10.1053/meta.2002.35197

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Article

Common variants in the lipoprotein lipase gene, but not those in the insulin receptor substrate-1, the beta3-adrenergic receptor, and the intestinal fatty acid binding protein-2 genes, influence the lipid phenotypic expression in familial combined hyperlipidemia.

Metabolism: clinical and experimental - 1 Oct 2002

Campagna Filomena, Montali Anna, Baroni Marco Giorgio, Maria Antonini Teresa, Ricci Giorgio, Antonini Roberto, Verna Roberto, Arca Marcello

Abstract excerpt

Familial combined hyperlipidemia (FCHL) is a common, atherogenic lipid disorder characterized by a variable phenotypic expression of hyperlipidemia. Variations in genes regulating fatty acid metabolism must be considered in the search for factors affecting the lipid phenotypic expression of FCHL. Therefore, we have evaluated the association of the common variants in the lipoprotein lipase (LPL) (D9N, N291S, and...

Topics

Alleles
Carrier Proteins
DNA
Fatty Acid-Binding Protein 7
Fatty Acid-Binding Proteins
Female
Heterozygote
Humans
Hyperlipidemias

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin Receptor Substrate Proteins

Intestinal Mucosa

Lipids

Lipoprotein Lipase

Male

Middle Aged

Neoplasm Proteins

Phenotype

Phosphoproteins

Source

Open in PubMed

Identifiers

PMID: 12370850
DOI: 10.1053/meta.2002.35197

Genes

LPL
FABP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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