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Article

CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5–AP-1 axis

13 Oct 2016

Abstract excerpt

Abnormal expression of cyclin-dependent kinase 5 (CDK5) has been found in several human cancers, whereas the role of CDK5 in the malignant development of colorectal cancer (CRC) has not been well characterized. Here we investigated the role of CDK5 in CRC and found that its expression was much higher in CRC tissues than that in normal tissues with a higher expression level of CDK5 closely correlating to advanced...

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PMID: 27735944
DOI: 10.1038/cddis.2016.333

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