Article
Hidden population substructures in an apparently homogeneous population bias association studies.
European journal of human genetics : EJHG - 1 Feb 2006
Berger Mario, Stassen Hans H, Köhler Karola, Krane Vera, Mönks Detlev, Wanner Christoph, Hoffmann Katrin, Hoffmann Michael M, Zimmer Michael, Bickeböller Heike, Lindner Tom H
Abstract excerpt
Linkage- and association-based approaches have been applied to attempt to unravel the genetic predisposition for complex diseases. However, studies often report contradictory results even when similar population backgrounds are investigated. Unrecognized population substructures could possibly explain these inconsistencies. In an apparently homogeneous German sample of 612 patients with type 2 diabetic and...
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