Article
Population structure, differential bias and genomic control in a large-scale, case-control association study.
Nature genetics - 1 Nov 2005
Clayton David G, Walker Neil M, Smyth Deborah J, Pask Rebecca, Cooper Jason D, Maier Lisa M, Smink Luc J, Lam Alex C, Ovington Nigel R, Stevens Helen E, Nutland Sarah, Howson Joanna M M, Faham Malek, Moorhead Martin, Jones Hywel B, Falkowski Matthew, Hardenbol Paul, Willis Thomas D, Todd John A
Abstract excerpt
The main problems in drawing causal inferences from epidemiological case-control studies are confounding by unmeasured extraneous factors, selection bias and differential misclassification of exposure. In genetics the first of these, in the form of population structure, has dominated recent debate. Population structure explained part of the significant +11.2% inflation of test statistics we observed in an...
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