Article
Unbiased methods for population-based association studies.
Genetic epidemiology - 1 Dec 2001
Devlin B, Roeder K, Bacanu S A
Abstract excerpt
Large, population-based samples and large-scale genotyping are being used to evaluate disease/gene associations. A substantial drawback to such samples is the fact that population substructure can induce spurious associations between genes and disease. We review two methods, called genomic control (GC) and structured association (SA), that obviate many of the concerns about population substructure by using the...
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