Allele-specific inhibition of divergent protein tyrosine phosphatases with a single small molecule.

Abstract excerpt

A central challenge of chemical biology is the development of small-molecule tools for controlling protein activity in a target-specific manner. Such tools are particularly useful if they can be systematically applied to the members of large protein families. Here we report that protein tyrosine phosphatases can be systematically 'sensitized' to target-specific inhibition by a cell-permeable small molecule,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drug Design
• Share to Drug Evaluation, Preclinical