Article
Biochemical Mechanisms of Resistance to Small-Molecule Protein Kinase Inhibitors
3 Jan 2010
Abstract excerpt
Protein kinases have emerged as one of the most frequently targeted families of proteins in drug discovery. While the development of small-molecule inhibitors that have the potency and selectivity necessary to be effective cancer drugs is still a formidable challenge, there have been several notable successes in this area over the past decade. However, in the course of the clinical use of these inhibitors, it has...
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