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Article

Enhanced spontaneous metastasis in bikunin-deficient mice.

International journal of cancer - 1 May 2006

Yagyu Tatsuo, Kobayashi Hiroshi, Matsuzaki Hidenori, Wakahara Kiyoshi, Kondo Toshiharu, Kurita Noriyuki, Sekino Hideo, Inagaki Kiyokazu

Abstract excerpt

Previously, we showed that bikunin, a Kunitz-type protease inhibitor, inhibits invasion and metastasis in several types of cancer cells possibly through suppression of upregulation of urokinase-type plasminogen activator (uPA) expression. Bikunin corresponds to a light chain of the inter-alpha inhibitor. To explore critical role of endogenous bikunin, we used bikunin knockout (Bik-/-) mice. Here, we show that 1)...

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Identifiers

PMID: 16331631
DOI: 10.1002/ijc.21293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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