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Article

Genetic background and 227Thorium as risk factors in biologically based models for induction of bone cancer in mice.

Radiation and environmental biophysics - 1 May 2012

Heidenreich W F, Rosemann M

Abstract excerpt

We explore the potential for the biologically based two-stage clonal expansion model to make statements about the influence of genetic factors on the steps in the model. We find evidence that the different susceptibility of BALB/C and CBA/Ca mice to bone cancer after (227)Thorium injection may be mostly due to different promotional responses to radiation. In BALB/C × CBA/Ca back-crossed mice, we analyzed the...

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PMID: 22466086
DOI: 10.1007/s00411-012-0409-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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