Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks.

Breast cancer research and treatment - 1 Sept 2007

Jakubowska Anna, Gronwald Jacek, Menkiszak Janusz, Górski Bohdan, Huzarski Tomasz, Byrski Tomasz, Edler Lutz, Lubiński Jan, Scott Rodney J, Hamann Ute

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR), a key regulatory enzyme in the metabolism of folate, is suspected to play a role in the etiology of cancer, via its effects on DNA methylation and nucleotide synthesis. In this study we have investigated the effect of two functional polymorphisms of the MTHFR gene, MTHFR_677_C > T and MTHFR_1298_A > C, on breast and ovarian cancer risk in Polish BRCA1 mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Mass Index
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Genes, BRCA1

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Ovarian Neoplasms

Share to Poland

Source

Identifiers

PMID: 17063264
DOI: 10.1007/s10549-006-9417-3

Genes

MTHFR
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks.PMID 17063264Read ↗

A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in breast cancer.Semantic proximity Read ↗

ASSOCIATION OF MTHFR A1298C POLYMORPHISM WITH BREAST CANCER AND/OR OVARIAN CANCER RISK: AN UPDATED META-ANALYSIS.Semantic proximity Read ↗

MTHFR polymorphisms and breast cancer riskSemantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls.Semantic proximity Read ↗

Polymorphisms in the MTHFR gene are associated with breast cancer.Semantic proximity Read ↗

Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in breast cancer risk in a population in Northeast Brazil.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in breast cancer: a Sardinian preliminary case-control studySemantic proximity Read ↗

Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele.Semantic proximity Read ↗

MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibilitySemantic proximity Read ↗

MTHFR C677T and A1298C Polymorphisms in Breast Cancer, Gliomas and Gastric Cancer: A Review.Semantic proximity Read ↗

Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.