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Article

Mitochondrial tumour suppressors: a genetic and biochemical update.

Nature reviews. Cancer - 1 Nov 2005

Gottlieb Eyal, Tomlinson Ian P M

Abstract excerpt

Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded mitochondrial proteins (SDHB, SDHC and fumarate hydratase) have been implicated in tumour susceptibility. Mutations in these proteins are principally involved in familial predisposition to benign tumours, but the spectrum of inherited lesions is increasingly...

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Source

Identifiers

PMID: 16327764
DOI: 10.1038/nrc1737

Genes

SDHB
SDHC
SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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