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Article

A role for mitochondrial enzymes in inherited neoplasia and beyond.

Nature reviews. Cancer - 1 Mar 2003

Eng Charis, Kiuru Maija, Fernandez Magali J, Aaltonen Lauri A

Abstract excerpt

Mitochondrial defects have been associated with neurological disorders, as well as cancers. Two ubiquitously expressed mitochondrial enzymes--succinate dehydrogenase (SDH) and fumarate hydratase (FH, fumarase)--catalyse sequential steps in the Krebs tricarboxylic-acid cycle. Inherited heterozygous mutations in the genes encoding these enzymes cause predispositions to two types of inherited neoplasia syndromes...

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Identifiers

PMID: 12612654
DOI: 10.1038/nrc1013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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