Article
Involvement of polyubiquitin chains via specific chain linkages in stress response in mammalian cells.
Biological & pharmaceutical bulletin - 1 Dec 2005
Fujimuro Masahiro, Nishiya Tadashi, Nomura Yasuyuki, Yokosawa Hideyoshi
Abstract excerpt
Polyubiquitination plays key roles in various proteasome-dependent and independent cellular events. To elucidate roles in stress response of polyubiquitin chains formed via specific chain linkages in mammalian cells, we established NIH3T3 stable cell lines that are capable of conditionally expressing K29R, K48R and K63R ubiquitin mutants, in which the Lys29, Lys48 and Lys63 residues of ubiquitin had been changed...
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