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Yeast polyubiquitin gene UBI4 deficiency leads to early induction of apoptosis and shortened replicative lifespan.

Cell stress & chaperones - 1 Jul 2018

Zhao Wei, Zhou Tao, Zheng Hua-Zhen, Qiu Kun-Pei, Cui Hong-Jing, Yu Hui, Liu Xin-Guang

Abstract excerpt

Ubiquitin is a 76-amino acid protein that is highly conserved among higher and lower eukaryotes. The polyubiquitin gene UBI4 encodes a unique precursor protein that contains five ubiquitin repeats organized in a head-to-tail arrangement. Although the involvement of the yeast polyubiquitin gene UBI4 in the stress response was reported long ago, there are no reports regarding the underlying mechanism of this...

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Identifiers

PMID: 29116578
DOI: 10.1007/s12192-017-0860-3
PMCID: PMC6045546

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SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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