Article
Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2014
Chong Robert A, Wu Kenneth, Spratt Donald E, Yang Yingying, Lee Chan, Nayak Jaladhi, Xu Ming, Elkholi Rana, Tappin Inger, Li Jessica, Hurwitz Jerard, Brown Brian D, Chipuk Jerry Edward, Chen Zhijian J, Sanchez Roberto, Shaw Gary S, Huang Lan, Pan Zhen-Qiang
Abstract excerpt
Lysine 48 (K48)-polyubiquitination is the predominant mechanism for mediating selective protein degradation, but the underlying molecular basis of selecting ubiquitin (Ub) K48 for linkage-specific chain synthesis remains elusive. Here, we present biochemical, structural, and cell-based evidence demonstrating a pivotal role for the Ub Y59-E51 loop in supporting K48-polyubiquitination. This loop is established by a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.