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Article

The transmission of mutation effects in a multiprotein machine: A comprehensive metadynamics study of the cardiac thin filament.

Protein science : a publication of the Protein Society - 1 Dec 2024

Ghanta Krishna Prasad, Castillo Romi L, Tardiff Jil C, Schwartz Steven D

Abstract excerpt

The binding of Ca2+ ions within the troponin core of the cardiac thin filament (CTF) regulates normal contraction and relaxation. Mutations within the troponin complexes are known to alter normal functions and result in the eventual development of cardiomyopathy. However, despite the importance of the problem, detailed microscopic knowledge of the mechanism of pathogenic effect of point mutations and their...

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Identifiers

PMID: 39548812
DOI: 10.1002/pro.5215
PMCID: PMC11568392

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