Article
Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features.
International journal of cancer - 1 Dec 2006
Buttitta Fiamma, Barassi Fabio, Fresu Giuseppina, Felicioni Lara, Chella Antonio, Paolizzi Diego, Lattanzio Giuseppe, Salvatore Simona, Camplese Pier P, Rosini Sandra, Iarussi Teodorico, Mucilli Felice, Sacco Rocco, Mezzetti Andrea, Marchetti Antonio
Abstract excerpt
Activating mutations in the tyrosine kinase domain of the HER2 gene have recently been reported in lung adenocarcinomas, mainly in East Asian patients. Our study was devised to evaluate the prevalence and nature of HER2 mutations in lung adenocarcinomas from Caucasian patients. The mutational status of the HER2 gene was evaluated in 403 lung adenocarcinomas by PCR-single strand conformation polymorphism analysis...
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